5 Best NMN Supplements of 2023: Reviews & Buyers Guide

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The world of health supplements is vast and ever-changing, with new products continually entering the market. As we enter the second half of 2023, one category of supplements gaining significant attention thanks to the likes of Joe Rogan, Andrew Huberman, and David Sinclair is NMN (nicotinamide mononucleotide). These promising supplements have become increasingly popular due to their potential longevity and cellular health benefits.

I have personally been taking NMN for the last five years. After using NMN bought on Amazon that contained none of the amounts of NMN claimed on the bottle, I began vigorously testing and trying every NMN brand under the sun. This has allowed me to come up with the following list of the best NMN supplements on the market.

NMN is a precursor to NAD+ (nicotinamide adenine dinucleotide), a critical molecule that plays a role in various cellular processes, including energy metabolism, DNA repair, and maintaining overall cellular health. Research has shown that as we age, NAD+ levels decrease, which may contribute to the development of age-related diseases and a decline in overall health. NMN supplements have been suggested to help maintain and boost NAD+ levels in the body, thus promoting cellular health and potentially slowing down aging processes.

This article will explore the top five NMN supplements available this year based on various factors such as efficacy, formulation, quality, consumer reviews, and my own personal experiences. By the end of this article, you’ll have a comprehensive understanding of each supplement and be well-equipped to make an informed decision for your health journey.

Top 5 NMN Supplements of 2023

Best Overall: Renue by Science

Renue by Science has emerged as a leading NMN product in the market due to its unique combination of advanced formulation and scientific backing. I have personally been taking Renue by Science Pure NMN Powder for the last year and even did an in-depth review of my experience after 90 days. Consequently, consumers are seeking the most effective and reliable NMN products, and Renue by Science has managed to address this demand with its exceptional offering.

The success of Renue by Science’s NMN product can be attributed to its dedication to rigorous research and development processes. By maintaining a solid foundation in cutting-edge scientific studies and incorporating the most recent discoveries, they have created an NMN product that stands out among competitors. Additionally, the company prioritizes transparency, ensuring customers have access to all relevant information about the product, its safety, and its potential benefits for health and wellness.

Moreover, Renue by Science’s commitment to quality control guarantees that their NMN product remains consistent and reliable in delivering the desired results. These factors have contributed to the establishment of Renue by Science as a trusted brand in the market and a top choice for consumers seeking a high-quality NMN product. Solid scientific research and a stringent focus on customer satisfaction have allowed Renue by Science to create a genuinely exceptional NMN offering. In addition, your dollar goes much further with Renue by Science than with any other brand. You can get 100 grams for less than $100 (even cheaper if you use code ‘brainflow’ for 10% off), which will last you an astounding six months if taking 500mg per day.

Advanced Delivery System

Renue by Science’s NMN Pure Powder stands out due to its advanced delivery system. This specialized system ensures that the NMN (Nicotinamide Mononucleotide) molecules are efficiently absorbed by the body, leading to higher bioavailability than other products. Incorporating nanotechnologies in their formulation, Renue by Science has developed an NMN product with improved solubility and absorption properties.

The delivery system relies on nanoparticles, typically less than 1000 nm in diameter, allowing for greater penetration and absorption within the gastrointestinal tract. This increased absorption allows for more effective delivery of NMN molecules into cells, ensuring optimal function and benefits.

RELATED READING: Dr. Andrew Huberman’s Science-Backed Supplement Stack

Optimized Dose

Renue by Science’s NMN Pure Powder is also designed with an optimized dose, tailored to provide the most efficient and effective results possible. Each scoop contains 500mg of NMN, so you can easily adjust depending on your feelings. By carefully determining the ideal dosage range, Renue by Science ensures its product can lead to higher bioavailability and rapid onset of action. I personally started with 250mg per day, slowly working myself up to 1 gram per day.

This approach not only increases the benefits experienced by consumers but also promotes better patient compliance due to its quick and efficient absorption. Overall, Renue by Science’s advanced delivery system and optimized dose contribute to the superior effectiveness of their NMN product in supporting cellular health and function.

Backed by Science

Renue by Science’s NMN product has undergone clinical studies to ensure its safety and effectiveness. Numerous participants experienced increased NAD+ levels within their cells, alongside improved overall health and well-being. The studies carefully considered the NMN product’s dosage, duration, and efficacy and monitored for any potential side effects.

Some key findings from these clinical trials include:

  • Increased energy levels: Participants reported a noticeable enhancement in their daily energy levels and overall stamina.
  • Improved cognitive functions: Participants experienced improvements in their memory, attention, and problem-solving skills.
  • Enhanced metabolism: The NMN product contributed to increased metabolic rates, enabling participants to maintain a healthier weight and enjoy a more active lifestyle.

These outcomes highlight the effectiveness of Renue by Science’s NMN product and its potential benefits to consumers.

Third-Party Testing

Renue by Science employs independent third-party laboratories to conduct comprehensive testing on their NMN products to guarantee product safety and effectiveness. These tests include analyses for purity, potency, and the absence of contaminants.

By utilizing third-party testing, Renue by Science provides an unbiased assessment of their NMN products, ensuring customers receive the highest quality supplements—this commitment to transparency and quality positions Renue by Science as a trusted leader in the NMN market. You can pick up Renue by Science Pure NMN Powder on their website, don’t forget code ‘brainflow’ to save 10%!

Close Second: Prohealth Longevity

Prohealth Longevity is a reputable manufacturer offering a range of NMN supplements to support cellular health and promote healthy aging. Their flagship product is their NMN Pro 1000 Enhanced Aborption Capsules, which feature high-availability Uthever NMN. I personally have tried their products and was highly impressed. One of their popular products is the Prohealth NMN Pro Lozenges, which provide 250 mg of NMN per lozenge.

Customers have shared their experiences with the Prohealth NMN supplements through reviews, highlighting their satisfaction with the product. Most users report positive effects on energy levels, overall health, and well-being. Prohealth Longevity is dedicated to staying up to date with the latest NMN scientific research, ensuring their products are of high quality and effective.

In addition to the NMN Pro Lozenges, ProHealth Longevity offers a variety of other NMN supplement forms, including liposomal, sublingual, standard, nasal spray, and transdermal options. This allows customers to choose the most suitable supplement form according to their preferences and needs. When it comes to price, ProHealth rings in at a slightly higher price point than Renue by Science, but their quality is unmatched. For example, you can get 100 grams of pure NMN for $100 at Renue by Science vs $144.95 at ProHealth for their powdered NMN.

Prohealth Longevity’s customer service is commendable, with a responsive and knowledgeable team available to answer any questions or concerns their customers may have regarding their NMN supplements. This level of support helps build trust and fosters a strong relationship between the company and its customers.

Prohealth Longevity establishes itself as a reliable source for those interested in improving their cellular health and promoting healthy aging through NMN by offering a range of high-quality NMN supplements and providing excellent customer service. You can try ProHealth Longevity by using code ‘brainflow’ for 15% off your order at checkout.

Third Place: Double Wood NMN

Double Wood NMN is a popular choice for those seeking an effective and reliable NMN supplement. I’ve used a variety of supplements from Double Wood in the past and have been impressed by their commitment to high-quality ingredients while also being able to maintain a favorable price point.

Double Wood provides high-quality nicotinamide mononucleotide in a potent formulation to support cellular health and longevity. Double Wood NMN values transparency in its manufacturing process and works to ensure that its product is of the highest quality. Consumers can trust this brand to deliver an NMN supplement that will truly make a difference in their health and longevity.

While there is no questioning Double Woods’s quality, they tend to have a higher price point than brands such as Renue by Science and ProHealth. For example, you can get 100 grams of NMN Pure Powder from Renue for under $100. In contrast, Double Wood gives you 30 grams of NMN powder for around $130.

Honorable Mention: Wonderfeel Youngr

Wonderfeel Youngr is a famous brand in the NMN supplement market. Their product is specifically designed to promote longevity and healthy aging. Wonderfeel Youngr uses a liposomal formulation to ensure optimal bioavailability and absorption of the NMN compound. This brand is committed to providing a high-quality, effective product supporting the body’s natural processes.

Wonderfeel Youngr’s NMN solution contains more than just NMN. This all-in-one longevity supplement contains 100mg trans-resveratrol, 50mg olive fruit extract, 4mg of ergothioneine, and even 20mcg of Vitamin D.

Wonderfeel Youngr receives an honorable mention due to the price point. For $88, you’re getting just 27 grams of NMN. This beats Double Wood on price point, but your dollar goes much further with Renue by Science, with NMN for less than $1 per gram.

Honorable Mention: OMRE NMN + Resveratrol

Omre NMN + Resveratrol is a cutting-edge supplement specially designed for individuals looking to support healthy aging. As a health-conscious person, I find this product intriguing due to its combination of ultra-pure nicotinamide mononucleotide (NMN) and resveratrol. Both ingredients have been widely researched for their potential age-related health benefits.

Starting with NMN, it’s a precursor to a crucial molecule called NAD+ (Nicotinamide Adenine Dinucleotide), which plays a vital role in cellular energy production and DNA repair. The natural decline of NAD+ levels is associated with aging and age-related conditions. By including NMN in their formula, Omre aims to boost cellular NAD+ levels, potentially helping to maintain overall health and well-being.

Resveratrol, on the other hand, is a powerful antioxidant found in red grapes, red wine, and certain fruits, and it’s been extensively studied for its potential anti-aging effects. In the Omre supplement, the resveratrol is 98% pure, enhancing its bioavailability and effectiveness.

Moreover, their formula uses research-backed doses, ensuring the supplement stays true to its potential benefits. The 98% pure NMN is blended with the 98% Resveratrol, both supplied at a 500mg dose. Also, the price point on Omre NMN isn’t that bad. For $60, you only get about 15 grams of NMN and 15 grams of resveratrol. If there were just NMN in this product, it likely wouldn’t even make this list of best NMN supplements, but adding resveratrol in a 1:1 ratio makes a huge difference.

To sum it up, the Omre NMN + Resveratrol supplement for 2023 promises great potential in supporting healthy aging by combining two potent ingredients – nicotinamide mononucleotide and resveratrol – in a well-formulated and research-backed product.

Factors to Consider When Choosing NMN Supplements

Purity and Quality

When selecting NMN supplements, it’s essential to prioritize purity and quality. High-quality supplements should be free of contaminants and meet or exceed industry standards for purity. Look for products that have been independently tested and verified for their purity and potency (every product in this review has been), as this will ensure you are getting a reliable and practical supplement.


Bioavailability refers to the proportion of supplements your body can effectively absorb and utilize. Different NMN supplements may have varying bioavailability levels, impacting their effectiveness. Opt for supplements with proven high bioavailability profiles to increase the chances of obtaining the desired effects.


Different NMN supplements might have varying absorption rates, affecting their efficacy. Choose a supplement designed to enhance absorption, such as one encapsulated in liposomes or emulsions. Renue by Science’s Liposomal NMN is one of the best on the market regarding absorption. These formulations can enhance the absorption of NMN in your digestive system, improving the overall effectiveness of the supplement.


It is crucial to select an NMN supplement backed by robust, independent research, demonstrating its efficacy in promoting various health benefits. Opt for products with clinical studies supporting their effectiveness in cellular health, such as anti-aging, energy production, and overall well-being. Both Renue by Science and ProHealth NMN supplements are backed by innumerable studies.

Side Effects and Risks

As with any dietary supplement, it’s essential to consider the potential side effects and risks associated with NMN supplementation. Most NMN supplements are generally safe and well-tolerated, but some individuals may experience mild side effects, including digestive issues or skin reactions. Always start with the recommended dosage, and consult with your healthcare provider if you have any concerns regarding NMN supplements’ safety or potential side effects.

Remember to weigh these factors carefully when choosing the right NMN supplement for your needs. By prioritizing purity, quality, bioavailability, absorption, and efficacy and considering potential side effects and risks, you can make an informed decision that will best support your health and wellness goals.

RELATED READING: Does Andrew Huberman Take NMN?

NMN and NAD+

How NMN Boosts NAD+ Levels

Nicotinamide mononucleotide (NMN) is a precursor to the essential molecule NAD+ (nicotinamide adenine dinucleotide). By supplementing with NMN, it can effectively boost NAD+ levels in the body. This occurs when NMN is converted to nicotinamide riboside (NR), which is then transformed into NAD+ through a series of enzymatic reactions. In this way, NMN supplementation supports the synthesis and maintenance of adequate NAD+ levels, enabling numerous health benefits.

Health Benefits of NAD+

NAD+ is vital in various cellular processes, contributing to overall health and well-being. Some of the critical health benefits of maintaining optimal NAD+ levels include:

  • Energy production: NAD+ is essential for producing adenosine triphosphate (ATP), the primary energy source in cells.
  • DNA repair: NAD+ supports DNA repair mechanisms, promoting genomic stability and reducing the risk of mutations that can lead to diseases like cancer.
  • Cellular aging: NAD+ has been linked to the activation of certain enzymes, specifically sirtuins, which help regulate cellular processes related to aging and longevity.
  • Metabolic health: NAD+ plays a pivotal role in regulating metabolism, impacting the conversion of nutrients to energy and helping maintain overall metabolic balance.

Age-Related NAD+ Decline

As we age, NAD+ levels tend to decline naturally. This decrease can reduce cellular function and contribute to several age-related health issues. Therefore, supplementing with NMN may help counter the effects of NAD+ depletion, supporting healthy aging and promoting healthspan.

One study found that NMN supplementation increases blood NAD+ concentrations and is safe and well-tolerated. Another study reported that long-term NMN supplementation improved arterial stiffness associated with cardiovascular health.

In summary, NMN supplements can help boost NAD+ levels, offering numerous potential health benefits. Individuals may support energy production, DNA repair, cellular aging, and metabolic health through supplementation while combatting age-related decline in NAD+ levels.

RELATED READING: Joe Rogan’s Anti-Aging Supplement Stack

Dosage and Administration

Recommended Dosing

Regarding NMN supplementation, dosages vary widely in studies, with amounts ranging from 100 to 1000 mg per day. It is essential to note that the optimal dose for each individual can differ, and factors such as age, weight, and overall health may contribute to the appropriate dosage. Numerous dosages work, but I had success starting at 250mg per day and slowly working my way up to 1000mg, taking 500mg in the morning and 500mg at night. It is advisable to consult a healthcare professional before starting any new supplement regimen.

As a starting point, the following dosages can be considered:

  • Low dose: 100-250 mg per day
  • Moderate dose: 250-500 mg per day
  • High dose: 500-1000 mg per day

It is generally recommended to start with a lower dose and gradually increase as needed based on individual response and tolerability.

Sublingual vs. Oral Administration

The method of administration can also play a role in the effectiveness of NMN supplementation. While oral administration, such as ingesting capsules or tablets, is the most common method, some studies have shown that sublingual administration (placing the supplement under the tongue until it dissolves) may lead to better absorption and improved insulin sensitivity.

Sublingual administration:

  • Pros: Potentially improved absorption, quicker onset of effects, bypasses first-pass liver metabolism.
  • Cons: May be less convenient or palatable than other methods, not all NMN supplements are available in sublingual form.

Oral administration:

  • Pros: Convenient, familiar, widely available in various supplement forms (capsules, tablets, etc).
  • Cons: Slower absorption, may be subject to first-pass liver metabolism, which can reduce bioavailability.

In conclusion, several factors, such as individual dosages and administration methods, can affect the potential benefits of NMN supplementation. Tailoring the dosage, planning according to personal preferences, and consulting a medical professional for guidance is crucial.

RELATED READING: Is Liposomal NMN the Best Form?

Added Ingredients and Combinatorial Supplements

When looking for the best NMN supplements in 2023, it is essential to consider not only the quality of the NMN itself but also the added ingredients and combinatorial supplements that can enhance its effectiveness. This section will explore four key ingredients commonly found in NMN supplements: Resveratrol, Ergothioneine, Hydroxytyrosol, and Vitamin D3.


Resveratrol is a natural antioxidant in grapes, red wine, and certain berries. In combination with NMN, resveratrol can provide synergistic effects for overall health and longevity. Studies have shown that resveratrol can help activate the sirtuin genes, which control cellular health and regulate metabolism. By combining NMN and resveratrol in a supplement, they can work together to improve cellular function and optimize the body’s energy production. ProHealth Longevity has an incredible combination NMN supplement called ProHealth Longevity NMN Pro Complete, which includes trans-resveratrol and TMG.


Ergothioneine, sometimes called “Ergo,” is an amino acid and powerful antioxidant found in mushrooms, beans, and other plant-based foods. It has been shown to protect cells from oxidative stress and damage, making it an excellent addition to NMN supplements. Its unique anti-inflammatory and antioxidant properties can positively affect overall health, especially when paired with NMN. Some NMN supplements include ergothioneine to help enhance the effects of NMN on cellular health and function.


Hydroxytyrosol, a naturally occurring compound found in olive fruit extract, possesses potent antioxidant and anti-inflammatory properties. It has been studied for its ability to protect against oxidative stress, promote healthy cardiovascular function, and boost the immune system. Hydroxytyrosol in NMN supplements can defend against age-related conditions and overall health benefits.

Vitamin D3

Vitamin D3 is essential for maintaining strong bones, immune system function, and regulating inflammation. It is commonly added to NMN supplements to support overall health and well-being. Specifically, Vitamin D3 can enhance the bioavailability of NMN, ensuring that the body effectively absorbs and utilizes this potent molecule. By including Vitamin D3 in an NMN supplement, users can experience the full range of benefits both substances have to offer.

Notable Researchers and Scientific Studies

One prominent researcher in NMN supplements is David Sinclair, a leading scientist in aging and lifespan research. Sinclair has his own impressive anti-aging supplement protocol. He has published numerous studies investigating the effects of NMN on cellular health and longevity in various organisms. His work has contributed to the growing knowledge of how NMN may help combat age-related decline and improve overall health. Dr. Sinclair has formulated a research-backed daily supplement stack designed to improve both healthspan and lifespan.

Several research studies have evaluated the potential benefits of NMN supplementation. For example, a study published in Nature investigated the effects of NMN on metabolism and energy production in mice. The researchers found that NMN improved mitochondrial function and overall metabolic health, suggesting that NMN supplementation could have potential therapeutic applications in managing age-related diseases.

In addition to animal studies, clinical trials have been conducted to assess the safety and efficacy of NMN supplements in humans. One such trial evaluated the effects of NMN on various health markers in older adults. The participants experienced improvements in various measures of cardiovascular health and glucose metabolism. This study is essential in understanding the potential benefits of NMN supplementation in humans.

The increasing amount of research on NMN supplements also involves the development of innovative delivery methods. A study published in the Journal of Food Process Engineering explored the use of ultrasonication and different wall materials to improve the stability and bioavailability of NMN in a lipid-based double emulsion template. This research aims to optimize the delivery of NMN and enhance its effectiveness as a supplement.

In conclusion, the research conducted by notable scientists like David Sinclair and the growing number of clinical trials and studies provides valuable insight into the potential benefits of NMN supplements. As the body of evidence expands, it becomes increasingly clear that NMN may play an essential role in promoting healthy aging and overall well-being.

Final Thoughts

In recent years, research has shown that NMN supplementation could benefit health and well-being. As a precursor to NAD+, it can help address the decline with age. Although more clinical trials are necessary to confirm these benefits, the findings are promising.

When choosing an NMN supplement, it’s crucial to consider the quality and reputation of the brand, as well as any certifications or third-party testing. Additionally, consulting a healthcare professional before starting any supplementation is always wise. In summary, the abovementioned NMN supplements exemplify quality and effectiveness based on customer reviews and brand reputation in 2023. In our opinion, you can’t go wrong with either Renue by Science or ProHealth Longevity. You can save a few bucks at either brand if you use code ‘brainflow’ at checkout.


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